BellBrook Labs has been awarded a $300,000 Phase I Small Business Innovative Research (SBIR) grant to develop and validate HTS assays for the discovery of small-molecule antagonists of TREX1.
Immunotherapy approaches such as immune checkpoint blockade are transforming oncology. However, many patients do not respond to existing agents, and new therapeutic strategies for eliciting immune responses to tumors are badly needed. It has recently become clear that activation of the stimulator of interferon (IFN) genes (STING) pathway is a critical step for initiating an antitumor T cell response in the tumor microenvironment (TME). TREX1 acts as a checkpoint on tumor cell immunity by preventing activation of the STING pathway in tumor cells. Upregulation of TREX1 by radiotherapy and chemotherapy interferes with their in situ vaccination effects. Multiple lines of evidence indicate that TREX1 antagonists could represent a new class of immune checkpoint blockers with broad and fundamental impact on cancer ...
