splicing

Cohesin mutations cause dysregulations in alternative splicing, contributing to tumor initiation and progression, a study finds. 

Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.

Researchers detail how viral proteins interact with host RNA to disrupt the cell’s ability to fight back against infection.

The way in which mRNA transcripts are cut can influence the elasticity of the organ.

It’s now clear that gene transcripts can be constructed in various ways, yet many questions remain about the process.

In brain samples from people with Alzheimer’s disease, the protein aggregates more strongly bound proteins involved in processing RNA, the same study finds.

A trial is recruiting patients to test the gene-editing technology’s ability to treat an inherited form of blindness caused by a mutation in the CEP290 gene.

Two studies contest the idea that the noncoding sequences are just “junk DNA,” demonstrating that they play important roles in the regulation of cell growth.

This year’s winners also include the developers of nusinersen, an oligonucleotide therapeutic for spinal muscular atrophy.

This year’s winners are C. David Allis, Michael Grunstein, John Glen, and Joan Steitz.

A proposed mechanism for how bearded dragons with male chromosomes hatch as females at high temperatures

At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.

Increasing the expression of an RNA splicing factor mimics dietary restriction, prolonging life in nematodes.