To Booster or Not: Scientists and Regulators Debate
To Booster or Not: Scientists and Regulators Debate
President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.
To Booster or Not: Scientists and Regulators Debate
To Booster or Not: Scientists and Regulators Debate

President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.

President Biden’s planned rollout of additional COVID-19 vaccine doses is set to begin next week, but questions remain about who should get them.

vaccine design
Rice-based Cholera Vaccine Induces Antibodies in Small Trial
Rice-based Cholera Vaccine Induces Antibodies in Small Trial
Alejandra Manjarrez | Jul 8, 2021
Immune-response levels to the edible vaccine varied among the subjects, possibly due to differences in the gut microbiome.
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Anthony King | Jul 1, 2021
More than a dozen vaccines for tuberculosis are currently being tested in clinical trials. Some use whole bacteria as BCG does, while others deliver protein subunits or genetic material carried by viral vectors.  
Tuberculosis: The Forgotten Pandemic
Tuberculosis: The Forgotten Pandemic
Anthony King | Jul 1, 2021
This month marks the 100-year anniversary of BCG, still the only approved vaccine against the lethal pathogen. But there are new vaccines for this wily foe on the horizon.
The Quest for a Universal Coronavirus Vaccine
The Quest for a Universal Coronavirus Vaccine
Diana Kwon | Jun 29, 2021
Scientists are on the hunt for a shot that will protect against not only SARS-CoV-2, but other members of its family that may emerge in the future.
Mucosal Vaccines Protect Mice from Viruses, Cancer
Mucosal Vaccines Protect Mice from Viruses, Cancer
Emma Yasinski | Jun 1, 2021
Scientists use a protein found in mucus membranes to ferry vaccines to the lymph nodes.
T Cell–Boosting Zika Vaccine Protects Mice from the Virus
T Cell–Boosting Zika Vaccine Protects Mice from the Virus
Ruth Williams | May 12, 2021
By avoiding the production of antibodies, something vaccines ordinarily induce, the immunization sidesteps the problem of antibody-dependent enhancement, which can amplify infection by a similar virus and is known to occur with dengue and Zika.
Pharma, US Government Plan for COVID-19 Booster Shots
Pharma, US Government Plan for COVID-19 Booster Shots
Jef Akst | Apr 16, 2021
It’s unclear how long protections against infection will last from the initial vaccinations, and health authorities say additional jabs will likely be necessary.
COVID-19 Vaccine Combos Aim to Boost Immunity
COVID-19 Vaccine Combos Aim to Boost Immunity
Asher Jones | Mar 9, 2021
Mix-and-match shots could simplify vaccine rollout and stimulate more-robust immune responses. Ongoing clinical trials will soon give answers.
What Pseudoviruses Bring to the Study of SARS-CoV-2
What Pseudoviruses Bring to the Study of SARS-CoV-2
Amanda Heidt | Feb 16, 2021
Engineered viruses that don’t replicate provide a tractable model for scientists to safely study SARS-CoV-2, including research into vaccine efficacy and emerging variants.
Vaccines Versus the Mutants
Vaccines Versus the Mutants
Anthony King | Feb 8, 2021
Facing new variants of SARS-CoV-2, some vaccines may offer more robust protection or be more easily redesigned to target them.
One-Shot COVID-19 Vaccine Prevents Severe Disease
One-Shot COVID-19 Vaccine Prevents Severe Disease
Asher Jones | Jan 29, 2021
Johnson & Johnson’s vaccine is less effective at preventing COVID-19 than other approved vaccines are, but experts say it could still be an important tool in curbing the pandemic.
The Promise of mRNA Vaccines
The Promise of mRNA Vaccines
Diana Kwon | Nov 25, 2020
Long before Moderna’s and Pfizer’s COVID-19 shots, scientists had been considering the use of genetically encoded vaccines in the fight against infectious diseases, cancer, and more.
Infographic: How Vaccines Train Innate Immunity
Infographic: How Vaccines Train Innate Immunity
Shawna Williams | Nov 1, 2020
A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.
How Some Vaccines Protect Against More than Their Targets
How Some Vaccines Protect Against More than Their Targets
Shawna Williams | Nov 1, 2020
As researchers test existing vaccines for nonspecific protection against COVID-19, immunologists are working to understand how some inoculations protect against pathogens they weren’t designed to fend off.
Johnson & Johnson Pauses COVID-19 Vaccine Trials
Johnson & Johnson Pauses COVID-19 Vaccine Trials
Amanda Heidt | Oct 13, 2020
The company voluntarily paused its studies, including one in Phase 3, after an unexplained illness in a patient.
Scientists Voice Concerns over Russian COVID-19 Vaccine Study
Scientists Voice Concerns over Russian COVID-19 Vaccine Study
Amanda Heidt | Sep 11, 2020
Almost 40 scientists have signed an open letter, citing odd patterns in the data and a lack of transparency after authors withheld the full data.
Infographic: Mix and Match
Infographic: Mix and Match
Ruth Williams | Jul 13, 2020
How llamas and superglue might lead to antiviral therapies
Jean Macnamara’s Multiple Causes, 1931
Jean Macnamara’s Multiple Causes, 1931
Catherine Offord | Jul 13, 2020
The medical scientist made important contributions to polio treatment and Australian environmental policy—despite substantial resistance.
FDA to Require 50 Percent Efficacy for COVID-19 Vaccines
FDA to Require 50 Percent Efficacy for COVID-19 Vaccines
Amanda Heidt | Jul 1, 2020
Vaccine experts divided on whether that level of protection is too low or too demanding.