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Depiction of human DNA helix.
An Epigenetic Strategy to Control Bad Cholesterol
Modifying markers on DNA allows scientists to lower cholesterol levels in mice, even long-term.
An Epigenetic Strategy to Control Bad Cholesterol
An Epigenetic Strategy to Control Bad Cholesterol

Modifying markers on DNA allows scientists to lower cholesterol levels in mice, even long-term.

Modifying markers on DNA allows scientists to lower cholesterol levels in mice, even long-term.

zinc finger nuclease

All Roads Lead to Genome Editing
Danielle Gerhard, PhD | Feb 9, 2024 | 6 min read
Shondra Pruett-Miller has taken many paths in her career with her love of genome editing always as a guiding light.
Illustration of DNA
Can “Gene Writing” Deliver What Gene Editing Can’t?
Dan Robitzski | Dec 12, 2022 | 10+ min read
A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?
Preliminary Results Point to Success of In Vivo Gene Editing
Carolyn Wilke | Feb 12, 2019 | 2 min read
Two studies show signs that the introduced DNA is functioning, but it’s too early to know if patients actually benefit.
Gene Editing Treats Mitochondrial Disorders in Mice
Catherine Offord | Sep 25, 2018 | 2 min read
Researchers used TALENs and zinc finger nucleases to correct disease-causing mutations.
Early Results of First In Vivo Gene-Editing Trial Encouraging
Kerry Grens | Sep 5, 2018 | 2 min read
Two patients who received Sangamo’s zinc finger–based treatment for Hunter syndrome have lower biomarkers of the condition, but no signs of new enzyme production.
Man Receives First In Vivo Gene-Editing Therapy
Kerry Grens | Nov 14, 2017 | 1 min read
The 44-year-old patient has Hunter syndrome, which doctors hope to treat using zinc finger nucleases.
First In Vivo Human Genome Editing to Be Tested in New Clinical Trial
Abby Olena, PhD | May 18, 2017 | 4 min read
Sangamo Therapeutics will use zinc finger nucleases to introduce the gene for a missing clotting factor into the livers of men with hemophilia B.
Gene Editing: From Roots to Riches
Amanda B. Keener | Oct 1, 2016 | 5 min read
Advances in genetic manipulation have simplified the once daunting task of rewriting a gene.
Rewritten in Blood
Ruth Williams | Sep 1, 2014 | 2 min read
A modified gene-editing technique corrects mutations in human hematopoietic stem cells.
Positive Developments on the HIV Front
Bob Grant | Mar 6, 2014 | 2 min read
A gene-editing protocol shows promise, and a second baby who was started on antiretroviral drugs soon after birth appears to be virus-free a year later.
Avant-Garde Science
Mary Beth Aberlin | Jun 1, 2012 | 3 min read
Why naked mole-rats and experimental gene therapies remind me of groundbreaking artists.
Messing with HIV
Jef Akst | Jun 1, 2012 | 1 min read
Sangamo Biosciences is putting a different spin on gene therapy. 
When Zinc Fingers Miss the Mark
Tia Ghose | Aug 7, 2011 | 3 min read
Two new techniques identify how often zinc fingers nucleases cleave off-target sites.
Zinc Fingers Bear Fruit
Bob Grant | Jul 18, 2011 | 1 min read
A method for precise gene editing is able to change disease-causing point mutations in human stem cell DNA.
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