For this article, Jim Kling interviewed University of Edinburgh geneticist Adrian Bird and Paul A. Wade, assistant professor in the department of pathology and laboratory medicine at Emory University School of Medicine in Atlanta. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

H.-H. Ng, Y. Zhang, B. Hendrich, C.A. Johnson et al., "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex," Nature Genetics, 23:58-61, September 1999 (Cited in 126 papers).

P.A. Wade, A. Gegonne, P.L. Jones, E. Ballestar et al., "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation," Nature Genetics, 23:62-6, September 1999 (Cited in 167 papers).

Histone acetylation and DNA methylation are two important chemical changes involved in the intricate choreography of transcriptional regulation.1,2 Scientists know that they work...

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