The Inequality of Drug Metabolism

Editor's Note: This is the fifth article in a series on sex-based differences in the biology of males and females. The final article in the series will cover sex-based differences in life expectancy. Lisa Damiani More than 30 years ago, researchers noted for the first time the pharmacokinetic differences between men and women. They found that women pass antipyrine, a drug used to study liver metabolism, more quickly than men; this occurred around ovulation and during the luteal phase of their m

Written byKaren Young Kreeger
| 6 min read

Register for free to listen to this article
Listen with Speechify
0:00
6:00
Share

Since then, just a few common drugs have been studied exclusively for sex differences.1 "We still have a long way to go," says Berg. "There aren't that many studies done on drugs in the market." In fact, it was only in 1999 that the National Institutes of Health held a scientific meeting on the subject.2 Investigation in this area is not merely academic; the issue of different metabolism rates has proven deadly for some women.

One reason these studies have not been done, according to Michael Smolensky, professor of environmental physiology, University of Texas School of Public Health at Houston, is funding is hard to come by. Also, the studies are complicated and require many subjects in many categories to conduct them properly. Susan Wood, the Food and Drug Administration's director of the Office of Women's Health, counters that the issue was, and still is, a question of clinical relevance. ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Twist Bio 
Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

cytiva logo
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo

Products

The Scientist Placeholder Image

Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery