Skip to main content

The piscidin adventure

Antimicrobial peptides exist in the epithelial tissues and blood cells of many vertebrates, but no antibiotic has been isolated from the mast cells of any animal. In November 15 Nature Umaporn Silphaduang and Edward Noga from North Carolina State University, Raleigh, US identified a family of peptide antibiotics that reside in the mast cells of fish. These 'piscidins' suggests that mast cells may participate in direct killing of microbial invaders.Silphaduang & Noga used tissues derived from

Written byTudor Toma
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00

Antimicrobial peptides exist in the epithelial tissues and blood cells of many vertebrates, but no antibiotic has been isolated from the mast cells of any animal. In November 15 Nature Umaporn Silphaduang and Edward Noga from North Carolina State University, Raleigh, US identified a family of peptide antibiotics that reside in the mast cells of fish. These 'piscidins' suggests that mast cells may participate in direct killing of microbial invaders.

Silphaduang & Noga used tissues derived from aquacultured, hybrid striped bass (Morone saxatilis x M. chrysops) and immunolocalized piscidins to mast cells in gill, skin, gut and blood vessels lining the viscera. In addition, they found that not all mast cells were positive for piscidins, indicating that piscidin-negative mast cells may be at a different stage of development or may have differentiated independently of the piscidin-positive lineage (Nature 2001, 414:268-269).

Peptide antibiotics may also be present in the mast cells ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Miltenyi
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi

Products

Sino Biological Logo

Sino Biological Launches European Newsletter Campaign with Exclusive Welcome Gifts

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo