1. How fat causes diabetes» There are new molecular links between obesity and diabetes—a high-fat diet in mice activates proteins associated with obesity, but these changes can be reversed by a well-known diabetes drug, suggesting the same pathway may also cause insulin-resistance.
J.H. Choi et al., Nature, 466:451-56, 2010. Evaluated by L. Hamann, Novartis; M. Andresen, OHSU; P. Webb, TMHRI. Free F1000 Evaluation
Splitting Two Birds with One Gene
2. A new metabolism » A novel metabolic pathway in the malaria parasite differs significantly from the classic Krebs cycle taught in textbooks, providing evidence that carbon metabolism can evolve.
K.L. Olszewski et al., Nature, 466:774-78, 2010. Evaluated by P. Roepe, Georgetown; R. Abraham, Pfizer. Free F1000 Evaluation
3. Double-edged gene » Two gene variants found commonly in African genomes, which appear to explain why African Americans have higher rates of kidney disease than ...
