Top 7 immunology papers

#1 T cell debate solved Mature T cells in the thymus are attracted to a molecule expressed by cells covering blood vessels, resolving a long standing puzzle of how cells escape into the body to fight infections. linkurl:(See our news story here.);http://www.the-scientist.com/blog/display/57375/ M.A. Zachariah, J.G. Cyster, "Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junction," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20413455?dopt=Abstract&holding=f1000,f1000m,isrctn 328:1129-35, 2010. linkurl:Eval by;http://f1000biology.com/article/zcq4z3zpg4t2nfr/id/3790964 Serge van de Pavert and Reina Mebius, VU Univ Med Center, Netherlands; Ivan Dzhagalov and Ellen Robey, University of California, Berkeley.

Neutrophil engulfing anthrax
bacteria.
Image: Wikimedia Commons/Etxrge

#2 No gray area for T cell activation Looking at the molecular dynamics of single T cells rather than the traditional technique of averaging the dynamics of multiple lysed cells, researchers saw that the T cell is activated in an "all or nothing" manner, challenging the conventional wisdom and demonstrating the power of the technique. S. Tay et al., "Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing," linkurl:__Nature,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20581820?dopt=Abstract&holding=f1000,f1000m,isrctn 466:267-71, 2010. linkurl:Eval by;http://f1000biology.com/article/h20ms86fstblbhh/id/4124960 Oberdan Leo and Muriel Moser, University of Brussels, Belgium; Yutaka Tagaya, National Cancer Institute. #3 Stem cells cater to infection When a host is infected by malaria, blood stem cells produce a new kind of progenitor that is better equipped to fight the disease, suggesting that some stem cells may be able to tailor their progeny to disease. N.N. Belyaev et al., "Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria," linkurl:__Nat Immunol,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20431620?dopt=Abstract&holding=f1000,f1000m,isrctn 11:477-85, 2010. linkurl:Eval by;http://f1000biology.com/article/lc2kd4l341mwddy/id/3857961 Jessy Deshane and David Chaplin, Univ of Alabama at Birmingham; Christian Engwerda Queensland Institute of Medical Research. #4 When good guys go bad One species of commensal bacteria in the gut is able to trigger Th17 helper T cells in a cascade that results in the development of autoimmune arthritis, providing further evidence for role of commensal bacteria in shaping the immune system. H.J. Wu et al., "Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells," linkurl:__Immunity,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20620945?dopt=Abstract&holding=f1000,f1000m,isrctn 32:815-27, 2010. linkurl:Eval by;http://f1000biology.com/article/7lj9yq044xkzl15/id/3882960 Caio Fagundes and Mauro Teixeira, Universidade Federal De Minas Gerais, Brazil; Allen Ho and Sarah Gaffen, University of Pittsburgh; E Charles Snow, University of Kentucky Medical Center; Rochelle Marie Hinman and John Cambier, National Jewish Medical and Research. #5 New gut ecosystem model? A new class of organisms may be cutting in on the classic, co-evolutionary, immune system-boosting tango between mammals and the beneficial bacteria that inhabit their guts: parasitic worms. Researchers found evidence the worms need gut bacteria to reproduce, suggesting they co-evolved and worms may play a larger-than-expected role in mammalian immunity. linkurl:(See our news story here.);http://www.the-scientist.com/blog/display/57492/ K.S. Hayes et al., "Exploitation of the intestinal microflora by the parasitic nematode Trichuris muris," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20538949?dopt=Abstract&holding=f1000,f1000m,isrctn 328:1391-94, 2010. linkurl:Eval by;http://f1000biology.com/article/wjgrzbj2nz0jbpr/id/3941956 Paul J Brindley, George Washington University; Adam Savage and Richard Locksley, University of California, San Francisco; Thomas Nutman, National Institutes of Health. #6 Suppressing TB-fighters Mycobacterium tuberculosis delays the immune response that would normally clear the infection by activating regulatory T cells that specifically suppress tuberculosis-fighting T -cells, offering another clue to how this infection becomes chronic. S. Shafiani et al., "Pathogen-specific regulatory T cells delay the arrival of effector T cells in the lung during early tuberculosis," linkurl:__J Exp Med,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20547826?dopt=Abstract&holding=f1000,f1000m,isrctn 207:1409-20, 2010. linkurl:Eval by;http://f1000biology.com/article/1zks69bp1w1t21m/id/3869956 Stanley Perlman, University of Iowa; Andrea Cooper, Trudeau Institute; Nandini Krishnamoorthy and Anuradha Ray, University of Pittsburgh. #7 Enzyme's role diminishes Lck kinase, an enzyme thought to play a major role in the signal transduction pathway that activates T cells, is present and equally active in both resting and activated T cells, suggesting Lck's activity alone isn't enough to push T cells from one state to the other -- and sending researchers back to the drawing board. K. Nika et al., "Constitutively active Lck kinase in T cells drives antigen receptor signal transduction," linkurl:__Immunity,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20541955?dopt=Abstract&holding=f1000,f1000m,isrctn 32:766-77, 2010. linkurl:Eval by;http://f1000biology.com/article/9794qz2kr1tg0d7/id/4154956 E Charles Snow, University of Kentucky Medical Center; Larry Kane, University of Pittsburgh. The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Immunology, as calculated on August 19, 2010. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:http://f1000.com.;http://f1000.com
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[27th July 2010]*linkurl:Top 7 immunology papers;http://www.the-scientist.com/blog/display/57563/
[20th July 2010]