Newt lung cells in early anaphaseNATIONAL INSTITUTE OF HEALTH
Researchers uncovered the pulses of external signaling factors that push resting cells to divide. In one phase, dialing up the levels of the signaling molecule p53 keeps cells from dividing, while another pathway increases expression of EGR1 and initiates cell division.
Y. Zwang et al., “Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals,” Mol Cell, doi: 10.1016/j.molcel.2011.04.017, 2011. Free F1000 Evaluation
Just before cells divide, chromosomes must duplicate and separate in a coordinated dance. This study showed that after the chromosomes double, a ring molecule called cohesion forms a tight band around them, then a molecule called separase cleaves the cohesion to allow the sister chromatids to synchronously drift ...
