Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

cancer biology
Contributors
Contributors
Asher Jones, Kerry Grens | Apr 1, 2021
Meet some of the people featured in the April 2021 issue of The Scientist.
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
Asher Jones | Apr 1, 2021
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
Infographic: Steps in Cancer Metastasis
Infographic: Steps in Cancer Metastasis
Shawna Williams | Apr 1, 2021
It’s now thought that in many cases, cancer cells disseminate from the primary tumor site early on and lay dormant for long periods rather than only venturing out from primary tumors at an advanced stage.
New Understanding of Metastasis Could Lead to Better Treatments
New Understanding of Metastasis Could Lead to Better Treatments
Shawna Williams | Apr 1, 2021
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.
Bisrat Debeb Models How Cancer Spreads to the Brain
Bisrat Debeb Models How Cancer Spreads to the Brain
Catherine Offord | Apr 1, 2021
From his student days in veterinary medicine in Ethiopia to running a lab on metastasis at MD Anderson Cancer Center, Debeb has a passion for understanding how living things work.
Infographic: The Role of Extrachromosomal DNA in Cancer
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
Microscopic Robots Deliver Drugs to the Brain
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
José Baselga, Renowned Oncologist, Dies at 61
José Baselga, Renowned Oncologist, Dies at 61
Asher Jones | Mar 22, 2021
The cancer researcher and executive vice president of AstraZeneca’s oncology research and development is well known for his role in the development of pivotal breast cancer therapies.