Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

cancer biology
Human Blood Harbors Cell-Free Microbial DNA
Human Blood Harbors Cell-Free Microbial DNA
Abby Olena | Jul 9, 2021
After controlling for high levels of bacterial contamination in their lab and reagents, researchers detect microbial genetic material in plasma samples from healthy people and cancer patients.
COVID-19 Vaccines Work in People with Cancer: Study
COVID-19 Vaccines Work in People with Cancer: Study
Marcus A. Banks | Jun 25, 2021
Moderna’s, Pfizer’s, and Johnson & Johnson’s shots all offered protection against the virus regardless of cancer type, although slightly less so in people with blood cancer.
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Marcus A. Banks | Jun 17, 2021
Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.
FDA-Led Consortium Details Improvements Needed in Liquid Biopsies
FDA-Led Consortium Details Improvements Needed in Liquid Biopsies
Marcus A. Banks | May 19, 2021
In the largest effort to date to standardize performance metrics of the cancer diagnostic across products, researchers say the products can likely detect advanced tumors reliably, but early-stage malignancies would remain a challenge.
Cancer Cells Parasitize Other Ones to Survive: Study
Cancer Cells Parasitize Other Ones to Survive: Study
Marcus A. Banks | May 13, 2021
Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.
No Transgenerational Effects of Chernobyl Radiation Found
No Transgenerational Effects of Chernobyl Radiation Found
Abby Olena | Apr 22, 2021
The genomes of the children of people exposed to fallout from the Chernobyl nuclear accident appear to carry no trace of the incident.
Cancer Cells Could Travel Through the Interstitium: Study
Cancer Cells Could Travel Through the Interstitium: Study
Marcus A. Banks | Apr 19, 2021
The continuous network of fluid-filled compartments crosses organ barriers and might serve as a conduit for tumor cells to spread.
Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Contributors
Contributors
Asher Jones, Kerry Grens | Apr 1, 2021
Meet some of the people featured in the April 2021 issue of The Scientist.
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
“Rogue” Protein Could Contribute to Humans’ High Cancer Rates
Asher Jones | Apr 1, 2021
A mutant protein called Siglec-XII may promote carcinoma progression in humans, but inactivation of its gene seems to avoid the problem, according to a study.
Infographic: Steps in Cancer Metastasis
Infographic: Steps in Cancer Metastasis
Shawna Williams | Apr 1, 2021
It’s now thought that in many cases, cancer cells disseminate from the primary tumor site early on and lay dormant for long periods rather than only venturing out from primary tumors at an advanced stage.
New Understanding of Metastasis Could Lead to Better Treatments
New Understanding of Metastasis Could Lead to Better Treatments
Shawna Williams | Apr 1, 2021
Recent insights, such as the recognition that disseminated cancer cells can lie dormant for years before seeding secondary tumors, suggest novel strategies for fighting metastatic disease.
Bisrat Debeb Models How Cancer Spreads to the Brain
Bisrat Debeb Models How Cancer Spreads to the Brain
Catherine Offord | Apr 1, 2021
From his student days in veterinary medicine in Ethiopia to running a lab on metastasis at MD Anderson Cancer Center, Debeb has a passion for understanding how living things work.
Infographic: The Role of Extrachromosomal DNA in Cancer
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
Microscopic Robots Deliver Drugs to the Brain
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
CAR Macrophages Tackle Challenges in Solid Cancer Treatment
Amanda Heidt | Mar 26, 2021
Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.
José Baselga, Renowned Oncologist, Dies at 61
José Baselga, Renowned Oncologist, Dies at 61
Asher Jones | Mar 22, 2021
The cancer researcher and executive vice president of AstraZeneca’s oncology research and development is well known for his role in the development of pivotal breast cancer therapies.
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Lisa Winter | Mar 11, 2021
Clinical trials were halted after the treatment’s vector that ferries in the healthy genetic sequence was identified in the genome of a patient’s cancer cells.
Bispecific Antibodies Treat Cancer in Mouse Models
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena | Mar 5, 2021
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.