Blind Mole Rats Use Junk DNA to Combat Cancer
Blind Mole Rats Use Junk DNA to Combat Cancer
Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.
Blind Mole Rats Use Junk DNA to Combat Cancer
Blind Mole Rats Use Junk DNA to Combat Cancer

Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.

Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.

cancer biology
DNA Methylation Influences Replication and Genome Organization
DNA Methylation Influences Replication and Genome Organization
Abby Olena | Sep 22, 2021
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.
Tumors Disrupt the Blood-Brain Barrier at a Distance
Tumors Disrupt the Blood-Brain Barrier at a Distance
Abby Olena | Sep 9, 2021
Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.
New Chernobyl Initiative Aims to Boost Research on the Area
New Chernobyl Initiative Aims to Boost Research on the Area
Stefan Weichert | Sep 1, 2021
Sergii Mirnyi, one of the people who helped clean up after the 1986 disaster, says he founded Chornobyl University to promote much-needed interdisciplinary research on the Chernobyl Exclusion Zone.
Gut Fungi Hamper Radiation Therapy in Mice with Cancer
Gut Fungi Hamper Radiation Therapy in Mice with Cancer
Rachael Moeller Gorman | Aug 11, 2021
Depleting intestinal fungi allows radiation to effectively fight cancer, likely because the microbes influence the antitumor immune response.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl | Jul 16, 2021
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Human Blood Harbors Cell-Free Microbial DNA
Human Blood Harbors Cell-Free Microbial DNA
Abby Olena | Jul 9, 2021
After controlling for high levels of bacterial contamination in their lab and reagents, researchers detect microbial genetic material in plasma samples from healthy people and cancer patients.
COVID-19 Vaccines Work in People with Cancer: Study
COVID-19 Vaccines Work in People with Cancer: Study
Marcus A. Banks | Jun 25, 2021
Moderna’s, Pfizer’s, and Johnson & Johnson’s shots all offered protection against the virus regardless of cancer type, although slightly less so in people with blood cancer.
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Cancer Metastasizes Via Fusion of Tumor and Immune Cells: Study
Marcus A. Banks | Jun 17, 2021
Researchers say evidence of hybridization between leukocytes and cancer indicates that this is a primary means of metastasis. Others disagree.
FDA-Led Consortium Details Improvements Needed in Liquid Biopsies
FDA-Led Consortium Details Improvements Needed in Liquid Biopsies
Marcus A. Banks | May 19, 2021
In the largest effort to date to standardize performance metrics of the cancer diagnostic across products, researchers say the products can likely detect advanced tumors reliably, but early-stage malignancies would remain a challenge.
Cancer Cells Parasitize Other Ones to Survive: Study
Cancer Cells Parasitize Other Ones to Survive: Study
Marcus A. Banks | May 13, 2021
Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.
No Transgenerational Effects of Chernobyl Radiation Found
No Transgenerational Effects of Chernobyl Radiation Found
Abby Olena | Apr 22, 2021
The genomes of the children of people exposed to fallout from the Chernobyl nuclear accident appear to carry no trace of the incident.
Cancer Cells Could Travel Through the Interstitium: Study
Cancer Cells Could Travel Through the Interstitium: Study
Marcus A. Banks | Apr 19, 2021
The continuous network of fluid-filled compartments crosses organ barriers and might serve as a conduit for tumor cells to spread.
Cancer May Be Driven by DNA Outside of Chromosomes
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Contributors
Contributors
Asher Jones, Kerry Grens | Apr 1, 2021
Meet some of the people featured in the April 2021 issue of The Scientist.