Top 7 in genetics and genomics

A snapshot of the most highly ranked articles in genetics and genomics, from Faculty of 1000

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Mitotic spindle in a human cell showing microtubules (green), chromosomes (blue), and kinetochores (red). IMAGE: AFUNGUY, WIKIMEDIA

1. New role for long noncoding RNA

By hitching a ride in loops formed by chromosomes, long intergenic noncoding RNAs (lincRNAs) can activate HOXA genes (a family of genes involved in cell patterning) over long ranges -- one of the few known examples of gene activation by lincRNAs.

K.C. Wang, et al., "A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression," Nature, 472:120-4, 2011. Evaluated by W. Lee Kraus, Univ of Texas; Panagiotis Ntziachristos and Iannis Aifantis, HHMI/New York Univ School of Medicine; Leonie Ringrose, Inst of Molecular Biotechnology GmbH, Austria; Pamela Geyer, Univ of Iowa. Free F1000 Evaluation

2. Separating chromosomes

For chromosomes to properly segregate during cell division, the spindle microtubules must be properly attached to protein complexes called kinetochores. ...

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