Top 7 in immunology

linkurl:1. How Tregs limit inflammation;http://f1000.com/5685958?key=sswwkkrpjfr7hxf T-regulatory cells can multiply their numbers by secreting the cytokine interleukin IL-35, which converts the population of T-cells involved in killing (effector T-cells) into regulatory cells that suppress inflammation, providing a new explanation for how inflammation is reeled in after an infection is cleared. L. W. Collison et al., "IL-35-mediated induction of a potent regulatory T cell population," linkurl:__Nat Immunol,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20953201?dopt=Abstract&holding=f1000%2Cf1000m 2010. Evaluated by Avinash Bhandoola, Univ Pennsylvania; Christian Engwerda, Queensland Inst of Med Res, Australia; Lieping Chen, Johns Hopkins Univ Sch of Med; David Serreze, The Jackson Lab; Xiaojing Ma, Weill Med Col of Cornell Univ; Stephen Cobbold, Univ Oxford; Stanley Perlman, Univ Iowa. linkurl:Free F1000 Evaluation;http://f1000.com/5685958?key=sswwkkrpjfr7hxf linkurl:2. Fighters in fat;http://www.f1000biology.com/article/sks77bpwcj55pkx/id/1438956 A new type of immune cell dubbed the "natural helper cell," found around the fat stores of the gut, activates B-cells and produces more Th2-type cytokines than other cells, possibly contributing to allergic immunity, clearance of parasitic worms and wound healing. K. Moro et al., "Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells," linkurl:__Nature,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20023630?dopt=Abstract&holding=f1000%2Cf1000m 463:540-44, 2010. Evaluated by Avinash Bhandoola Univ Penn; John Gordon Foster and Steve Ward, Univ Bath, UK; Troy Randall, Univ Rochester; Dale Umetsu, Children's Hosp Boston, Harvard Med Sch; Dhaya Seshasayee and Flavius Martin, Genentech; James Di Santo, Inst Pasteur, France; Richard Locksley, UCSF. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/sks77bpwcj55pkx/id/1438956

B cell
Image: Wikimedia

linkurl:3. Directed clean-up;http://f1000.com/6269956?key=bdgddhlz6kwm789 Neutrophils are attracted to an inflamed area in part to help clean-up bruised or dead tissue, but they can also contribute to the inflammation and cause additional damage if overstimulated. Researchers found that a hierarchy of signals directs neutrophils through healthy tissue to their target, and helps limit collateral damage from these cells. B. McDonald et al., "Intravascular danger signals guide neutrophils to sites of sterile inflammation," linkurl:__Science,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20947763?dopt=Abstract&holding=f1000%2Cf1000m 330:362-66, 2010. Evaluated by William A Muller, Northwestern Univ, Feinberg School of Med; Samantha Wang and Karsten Gronert, UC, Berkeley; Sharon Hyduk and Myron Cybulsky, Toronto Gen Hosp, Canada. linkurl:Free F1000 Evaluation;http://f1000.com/6269956?key=bdgddhlz6kwm789 linkurl:4. Allergy gets a new look;http://www.f1000biology.com/article/tfq5nmztbzzg2mw/id/5343957 The role of basophils, a type of white blood cell, in allergic reactions has recently become an area of controversy: While some recent studies support the old dogma that basophils are key components of allergic reaction, this new study adds to a linkurl:body of literature;http://www.the-scientist.com/2011/1/1/48/1/ suggests they are not involved at all -- specifically, that dendritic cells, not basophils, are critical for allergic inflammation. A.T. Phythian-Adams et al., "CD11c depletion severely disrupts Th2 induction and development in vivo," linkurl:__J Exp Med,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20819926?dopt=Abstract&holding=f1000%2Cf1000m 207:2089-96, 2010. Evaluated by Thomas Nutman, NIH; Marc A Williams, US EPA; Booki Min, Cleveland Clinic Foundation; Eric Denkers, Cornell Univ. linkurl:Free F1000 Evaluation;http://www.f1000biology.com/article/tfq5nmztbzzg2mw/id/5343957 linkurl:5. Tracking B-cell movement;http://f1000.com/6837956?key=g8f7jn6yc79cycx By applying GFP technology in a new way, authors tracked B-cell maturation in the lymph nodes as the cells move from an area of rapid proliferation to an area where B cells that produce the best antibodies are selected, and back again, and found an essential role of T helper cells in this transition. G.D. Victora et al., "Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter," linkurl:__Cell,__;http://www.ncbi.nlm.nih.gov/sites/entrez/21074050?dopt=Abstract&holding=f1000%2Cf1000m 143:592-605, 2010. Evaluated by Yinan Wang and Deepta Bhattacharya, Washington Univ in St. Louis; Naomi Harwood and Facundo Batista, Cancer Res UK, London Res Inst; Kai-Michael Toellner, Univ Birmingham, UK. linkurl:Free F1000 Evaluation;http://f1000.com/6837956?key=g8f7jn6yc79cycx linkurl:6. Cancer suppresses immune response;http://f1000.com/5685957?key=lsbjv32kdkkj93x Neutrophils, usually thought of as the first responders during infection, can suppress the inflammatory response to cancer when exposed to peptides from tumor cells, demonstrating a new way for tumors to evade the immune system, and hinting at novel targets for cancer immunotherapies.C. De Santo et al.,"Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A" linkurl:__Nat Immunol,__;http://www.ncbi.nlm.nih.gov/sites/entrez/20890286?dopt=Abstract&holding=f1000%2Cf1000m 11:1039-46, 2010. Evaluated by Dale Umetsu, Children's Hosp Boston, Harvard Med Sch; Alberto Mantovani, Inst Clin Humanitis, Univ Milan, Italy; William Seaman, UCSF. linkurl:Free F1000 Evaluation;http://f1000.com/5685957?key=lsbjv32kdkkj93x linkurl:7. Viruses fueled by recycled materials;http://f1000.com/7032958?key=0bg2grmzz04zhpd The Dengue virus co-opts autophagy, one of the cell's recycling mechanisms, in order to reuse host lipids that it then uses to drive its own replication, explaining where viruses get the energy to support their division.N.S. Heaton and G. Randall, "Dengue virus-induced autophagy regulates lipid metabolism," linkurl:__Cell Host Microbe,__;http://www.ncbi.nlm.nih.gov/sites/entrez/21075353?dopt=Abstract&holding=f1000%2Cf1000m 8:422-32, 2010. Evaluated by Muriel Mari and Fulvio Reggiori, Univ Med Cen Utrecht, Netherlands; P'ng Loke, NYU Langone Med Cen; Joeli Marrero and Sabine Ehrt, Weill Cornell Med Col. linkurl:Free F1000 Evaluation;http://f1000.com/7032958?key=0bg2grmzz04zhpd The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Immunology, as calculated on February 3, 2011. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit linkurl:http://f1000.com.;http://f1000.com
**__Related stories:__***linkurl:Top 7 papers in medicine;http://www.the-scientist.com/news/display/57969/
[31st January 2011]*linkurl:Top 7 in genetics and genomics;http://www.the-scientist.com/news/display/57923/
[18th January 2011]*linkurl:Top 7 immunology papers;http://www.the-scientist.com/news/display/57918/
[11th January 2011]

Top 7 in immunology

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