linkurl:1. How cilia talk; Primary (nonmotile) cilia need membrane proteins to send and receive extracellular signals as part of their role as a coordinator of signaling pathways, and new findings show how cilia retain those membrane proteins -- a barrier at the base of cilia made up of proteins called septins.
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Q. Hu et al., __Science__, 329:436-39, 2010. Evaluated by Y. Barral, ETH; M. Wirschell and W. Sale, Emory; H. Folsch, Northwestern; Y. Yamashita, UMich; M. Bettencourt-Dias, IGC; S. Feng and W. Guo, UPenn; M. Labouesse, CNRS; J. Axelrod, Stanford. linkurl:Free F1000 Evaluation; linkurl:2. Nickel allergy explained; Allergy to nickel plated jewelry is initiated because Toll-like receptor 4 (TLR4) binds and recognizes nickel in much the same way that it recognizes lipopolysaccharides, a component of the bacterial cell wall. M. Schmidt et al., __Nat Immunol__, 11:814-9, 2010. Evaluated by Marc Rothenberg, Cincinnati Children's Hosp Med Center; Caetano...
linkurl:3. Third one's the charm; T. Shimamura, et al., Science, 328:470-3, 2010. Evaluations by Louis De Felice, Virginia Commonwealth Univ; Baruch Kanner, Hebrew Univ Hadassah Medical School, Israel; Robert Vandenberg, Univ of Sydney, Australia; Gary Rudnick, Yale Univ School of Medicine. linkurl:Free F1000 Evaluation; linkurl:4. Source of mechanotransduction?; L. Kang, et al., Neuron, 67:381-91, 2010. Evaluations by Rachel Wilson, Harvard Medical School; Andy Groves, Baylor College of Medicine; Paul Garrity, Brandeis Univ; Roger Hardie, Univ of Cambridge. linkurl:Free F1000 Evaluation; linkurl:5. Shining new light on fMRI; J.H. Lee, et al., __Nature__, 465:788-92, 2010. Evaluations by Aina Puce, Indiana Univ.; Atsushi Iriki, RIKEN Brain Science Institute; Luis de Lecea, Stanford Univ. linkurl:Free F1000 Evaluation; linkurl:6. The many mutations of cancer;
Lung carcinomaWikimedia Commons
Z. Kan, et al., __Nature__, 466:869-73, 2010. Evaluations by Thomas Ried, National Cancer Institute; Donald Nierlich, UCLA; Silvio Gutkind, National Institute of Dental and Craniofacial Research. linkurl:Free F1000 Evaluation; 7. Guidance proteins in actionH. Liu, et al., __Cell__, 142:749-61, 2010. Evaluations by Yuxiao Wang and Xuewu Zhang, Univ of Tex Southwestern Med Ctr; Prasanta Hota and Matthias Buck, Case Western Res Univ; Guido Serini and Giulio Gabbiani, Univ Geneva. Free F1000 Evaluation

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