Week in Review: April 3–7

Virus triggers gluten intolerance in mice; UK bank offers clinic-ready hESC lines; researchers debate giant virus origins; cephalopods edit RNA; scientists screen noncoding genome with CRISPR

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Infecting mice with a human reovirus led to an immune response against dietary gluten and other signs of celiac disease, researchers from the University of Chicago and their colleagues reported in Science this week (April 6).

“It’s been hypothesized for decades that virus infection can trigger autoimmune processes,” said Herbert Virgin of the University of Washington who was not involved in the work. “This study provides an example of that phenomenon and some mechanistic insight into how this might work for celiac disease.”

Researchers can now apply to purchase ready-made human embryonic stem cell (hESC) lines from the UK Stem Cell Bank. All samples in the repository comply with the European Tissue and Cell Directives. Glyn Stacey, director of the resource, told The Scientist that his team made sure that all banked, clinic-ready hESC lines were produced according to these regulations “right from the donor selection, procurement of tissues, the ...

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