Week in Review: February 8–12

Targeting tumors with tumor-derived cells; effects of Neanderthal genes on human health; blocking chronic pain in mice; malignancies found in naked mole rats

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UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, ELEONORA DONDOSSOLAGenetically engineering circulating tumor cells (CTCs) to express an anticancer cytokine, scientists from University of New Mexico and their colleagues have successfully targeted tumors implanted in mice. The team’s results were published in PNAS this week (February 8).

“This paper is an elegant example of thinking outside the box,” said Elizabeth Comen of the Memorial Sloan Kettering Cancer Center in New York City who was not involved with the work. “To leverage the cancer cell’s powerful ability to travel all over the body against tumors is fascinating.”

MICHAEL SMELTZER, VANDERBILT UNIVERSITYHumans appear to have inherited from Neanderthals alleles linked to depression risk, among other traits, a team led by researchers at Vanderbilt University in Nashville, Tennessee, reported in Science this week (February 11).

“A number of previous studies have focused on individual genes,” said evolutionary geneticist Rasmus Neilsen of the University of California, Berkeley, who did not participate in the research. “But this is the first study that really systematically goes through and uses the knowledge we have about genetic variations in humans to ...

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