Week in Review: July 18–22

Organoids versus animal models; mapping the human cortex; how hyperglycemia affects the brain; delivering drugs to tumors with engineered bacteria; neurons compete for memory space

| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

Scientists are developing increasingly sophisticated in vitro mini organs, some that can even model human physiology. But these are unlikely to fully replace in vivo testing on animal models. Still, these organoids may supplant animal models for toxicology testing and similar applications.

“Organoids are a fantastic new tool to do research,” Denis Duboule of the École Polytechnique Fédérale de Lausanne in Switzerland told The Scientist. But when it comes to animal models, “I don’t see it as a replacement,” he said.

Researchers from Washington University School of Medicine in St. Louis have produced the most complete map of the human cortex to date, pinpointing 97 regions of this part of the brain previously unknown to neuroscience.

Studies on zebrafish and humans are beginning to highlight how persistent elevated blood sugar is linked to cognitive deficits.

Brain cells compete with one another for space in memory-storing groups called engrams. Scientists at ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Tracy Vence

    This person does not yet have a bio.
Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

fujirebio-square-logo

Fujirebio Receives Marketing Clearance for Lumipulse® G pTau 217/ β-Amyloid 1-42 Plasma Ratio In-Vitro Diagnostic Test

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours