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Week in Review: July 18–22

Organoids versus animal models; mapping the human cortex; how hyperglycemia affects the brain; delivering drugs to tumors with engineered bacteria; neurons compete for memory space 

Written byTracy Vence
| 3 min read

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Scientists are developing increasingly sophisticated in vitro mini organs, some that can even model human physiology. But these are unlikely to fully replace in vivo testing on animal models. Still, these organoids may supplant animal models for toxicology testing and similar applications.

“Organoids are a fantastic new tool to do research,” Denis Duboule of the École Polytechnique Fédérale de Lausanne in Switzerland told The Scientist. But when it comes to animal models, “I don’t see it as a replacement,” he said.

Researchers from Washington University School of Medicine in St. Louis have produced the most complete map of the human cortex to date, pinpointing 97 regions of this part of the brain previously unknown to neuroscience.

Studies on zebrafish and humans are beginning to highlight how persistent elevated blood sugar is linked to cognitive deficits.

Brain cells compete with one another for space in memory-storing groups called engrams. Scientists at ...

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