Week in Review: November 23–27

New mouse interneurons found; epigenetic effects of an antidepressant; defining “high-fat” diets; animal-inspired art

Written byTracy Vence
| 3 min read

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DANIEL BERGER, XIAOLONG JIANG, FABIAN SINZ, XAQ PITKOW, ANDREAS TOLIASIn creating the most comprehensive census of the mouse neocortex yet, scientists at the Baylor College of Medicine in Houston, Texas, and their colleagues identified three new subsets of interneurons. Their work was published in Science this week (November 26).

”[The team] took a very detailed, typically small-sample approach and applied it to a big survey,” said Arthur Toga, director of the Laboratory of Neuro Imaging in Los Angeles who was not involved in the study.

“[The study was] a truly impressive tour de force in terms of optimization of every experimental and analytical detail,” said Giorgio Ascoli of the Krasnow Institute for Advanced Study in Fairfax, Virginia, who was not involved in the work.

WIKIMEDIA, SCHUMINWEBWhat’s in a lab mouse’s “high-fat” diet, anyway? While these diets vary, they typically include lots of carbs and little fiber. And not controlling for the effects of these and other components of the food can affect nutritional experiments performed on mice.

“Is a high-fat defined diet we’re feeding the mouse really comparable to what a human is eating?” asked Matthew Ricci, science director of Brunswick, New ...

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