A powerful new tool to assess the functionality of the active proteins in any given cell -- the so-called reactome -- has been called into question. How would this recently developed "reactome array," described in a study published last October in Science, advance the field of functional genomics, and if it should fail, what would the ramifications be?
A biochip
Image: Flickr,
linkurl:Argonne Laboratory;http://www.flickr.com/photos/argonne/3397932229/
When Nobel Laureate linkurl:Richard Roberts,;http://nobelprize.org/nobel_prizes/medicine/laureates/1993/roberts-autobio.html currently the chief scientific officer of New England Biolabs, first read about the new technique, "it seemed too good to be true," he said. "It promised to do so much" -- uncover the functional identities of countless mystery genes -- "and seemed to do it very effectively". While current methods allow scientists to do this just one protein at a time, the reactome array would be able to look at hundreds of genes simultaneously. The array is comprised of nearly...
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