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Worried Sick

Expectations can make you ill. Fear can make you fragile. Understanding the nocebo effect may help prevent this painful phenomenon.

Written byMegan Scudellari
| 12 min read

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© BRYAN SATALINO

Something strange was happening in New Zealand. In the fall of 2007, pharmacies across the country had begun dispensing a new formulation of Eltroxin—the only thyroid hormone replacement drug approved and paid for by the government and used by tens of thousands of New Zealanders since 1973. Within months, reports of side effects began trickling in to the government’s health-care monitoring agency. These included known side effects of the drug, such as lethargy, joint pain, and depression, as well as symptoms not normally associated with the drug or disease, including eye pain, itching, and nausea. Then, the following summer, the floodgates opened: in the 18 months following the release of the new tablets, the rate of Eltroxin adverse event reporting rose nearly 2,000-fold.1

The strange ...

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