Worried Sick

Expectations can make you ill. Fear can make you fragile. Understanding the nocebo effect may help prevent this painful phenomenon.

Written byMegan Scudellari
| 12 min read

Register for free to listen to this article
Listen with Speechify
0:00
12:00
Share

© BRYAN SATALINO

Something strange was happening in New Zealand. In the fall of 2007, pharmacies across the country had begun dispensing a new formulation of Eltroxin—the only thyroid hormone replacement drug approved and paid for by the government and used by tens of thousands of New Zealanders since 1973. Within months, reports of side effects began trickling in to the government’s health-care monitoring agency. These included known side effects of the drug, such as lethargy, joint pain, and depression, as well as symptoms not normally associated with the drug or disease, including eye pain, itching, and nausea. Then, the following summer, the floodgates opened: in the 18 months following the release of the new tablets, the rate of Eltroxin adverse event reporting rose nearly 2,000-fold.1

The strange ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH