Sample isolation and preparation often creates a bottleneck in the execution and automation of high throughput processes. To address this issue, Millipore has recently adapted its MultiScreen Assay System to perform chromatographic separations. This adaptation enables researchers to purify many samples simultaneously and provides a platform that facilitates automation. The MultiScreen approach has been used successfully to perform several types of chromatographic separation (for example, size exclusion, reverse phase, and cationic exchange) and presumably can be used with any standard chromatography matrix.

Millipore Column Loader
The MultiScreen Assay System, developed in 1989, consists of two components: disposable 96-well filtration plate assemblies and a vacuum manifold. The well bottoms of the plates are not closed off with plastic, as one would find in a standard 96-well plate; rather the wells are sealed with a filter. The filter, combined with the patented underdrain, allows the plates to hold liquid securely for up...

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