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Courtesy of Shands HealthCare Marketing and Public Affairs SIMULATED PATIENT Facilities at the University of Florida's new $60 million brain institute include a computer-driven patient simulator. One of the simulator's inventors, Michael Good (center), UF associate professor of anesthesiology, directs a team of nurses and paramedics in an emergency room drill using the simulator. BRAIN TRUST A new $60-million facility makes the University of Florida in Gainesville a national nerve center for

Introductory general biology courses and textbooks cover a vast amount of material. They tend to stress the similarities of life at the molecular and cellular levels, with Homo sapiens considered but one of many species. For students wishing to learn specifically about the female body, or about differences between the sexes, these courses aren't usually appropriate. ANALOGY: Like women's absence in past medical tests and clinical trials, many problems have not been addressed in biology, anat

How proteins fold is a central mystery of the life process that for decades has eluded explanation. But biologists are getting help on the problem nowadays from physicists, who bring quantitative theorems and new technologies to the task of showing how one-dimensional amino acid sequences determine the three-dimensional shapes of proteins. Such knowledge could guide structure-based design of drugs to treat a range of diseases now thought to be caused by misshapen proteins. "We're just beginnin

Mice everywhere are breathing a collective sigh of relief. Soon, far fewer small laboratory animals will be routinely sacrificed to allow researchers to observe the after-effects of gene mutations or other experimental manipulations. Instead, investigators will be able to track the implications of those changes in living specimens in exquisite detail and for extended periods of time, thus painting a fuller, more accurate picture of what's going on and why. At least, that's the likely scenario i

The lobbyist credited his client. The client credited his lobbyist. Both praised scientists and legislators on the brink of an historic vote that would put the National Institutes of Health on the path to doubling its budget in five years. Congress, as of press time for The Scientist, was poised to pass a $500 billion legislative package that includes a $2 billion increase for the National Institutes of Health. The agency received $13.648 billion for 1998. Prior to the vote on the "omnibus" spe

BIOREMEDIATION TO THE PIGPEN It was a stinky summer at the EnviroPork hog facility near Larimore, N.D., with penalties pending for violating state odor regulations, and neighbors complaining loudly about the foul fragrance. Making matters worse, the manure lagoon associated with the facility threatened groundwater supplies. Happily, researchers from the University of North Dakota Energy and Environmental Research Center (EERC) had a low-tech solution: barley straw. Using a cannon, they shot a

Editor's Note: In the previous issue of The Scientist (12[20]:7, 14, Oct. 12, 1998), we published the first part of an excerpt from NO by Carl Djerassi. We met the chief protagonist of the book, an Indian scientist named Renu Krishnan, who has developed a drug called NONO-2 and a delivery system called MUSA. Guided by Martin Gestler, a hard-charging expert on biotechnology start-up companies, Krishnan has left academic research to found a company called SURYA. The previous extract described t

You have probably heard more than your share of Viagra jokes; a whole Web site is devoted to them. But impotence, or erectile dysfunction (ED), is no joke. According to a survey (H.A. Feldman et al., Journal of Urology, 151:54-61, 1994), more than 50 percent of men between 40 and 70 suffer from some degree of ED. The figure climbs to 67 percent at age 70. That's 20 to 30 million men, according to the National Institutes of Health. FIRST IN LINE: Viagra is actually the second drug approved t

On September 25 at the Hotel Pierre in New York City, seven prominent scientists, representing a generation of landmark discoveries in biology and medicine, stepped to the podium to receive this year's Albert Lasker Medical Research Awards, a coveted honor bestowed annually since 1946 by The Albert and Mary Lasker Foundation. The research of six of this year's recipients made possible groundbreaking discoveries in the field of cancer research. The research of the seventh, who received his award

A plan to screen pesticides, fungicides, and herbicides for endocrine disruptor activity could be bad news for the manufacturers of those synthetics, but good news for research in biocontrols, a natural alternative to those chemicals. Recently, the Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) recommended that about 15,000 commercial chemicals be tested for their interaction with reproduction and development (P. Smaglik, The Scientist, 12[18]:1, Sept. 14, 1998). Although

LEAVING HOWARD HUGHES After serving as the president of the Howard Hughes Medical Institute since 1987, Purnell W. Choppin has announced his resignation. "While my enthusiasm for the position I have been privileged to hold and my dedication to the Institute remain as intense as ever, I believe that it will be time for someone to take up the reins and lead HHMI into the new millennium," Choppin wrote in a letter to the institute's staff. He will remain in the position through 1999. Under Choppin

EDITOR'S NOTE: Carl Djerassi's novel NO concerns the development of a fictional, though close-to-life, drug and delivery system for the relief of male impotence. While the science in the novel is accurate, the book is a work of fiction. Nevertheless, some real-life characters, including Djerassi himself (a professor in the chemistry department at Stanford University), and other more or less disguised fictional characters based on real people make appearances in the book. In this issue and in t