Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin biosynthesis with a potential role in promoting colon carcinogenesis, but the mechanism of COX-2 overexpression remains unknown. In December 1 Journal of Clinical Investigation, Dan Dixon and colleagues from University of Utah, Salt Lake City, USA, show that altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.The COX-2 mRNA carries an A/U-rich element (ARE), a cis-acting
Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin biosynthesis with a potential role in promoting colon carcinogenesis, but the mechanism of COX-2 overexpression remains unknown. In December 1
The COX-2 mRNA carries an A/U-rich element (ARE), a
These results provide a mechanism to link the control of COX-2 expression at a posttranscriptional level and tumorigenesis. In the light of these findings other specific regulators of ...
A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.
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