Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin biosynthesis with a potential role in promoting colon carcinogenesis, but the mechanism of COX-2 overexpression remains unknown. In December 1 Journal of Clinical Investigation, Dan Dixon and colleagues from University of Utah, Salt Lake City, USA, show that altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.The COX-2 mRNA carries an A/U-rich element (ARE), a cis-acting
Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin biosynthesis with a potential role in promoting colon carcinogenesis, but the mechanism of COX-2 overexpression remains unknown. In December 1
The COX-2 mRNA carries an A/U-rich element (ARE), a
These results provide a mechanism to link the control of COX-2 expression at a posttranscriptional level and tumorigenesis. In the light of these findings other specific regulators of ...
A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.
View this Issue
In this webinar, Daryl Cole will share insights into the high-throughput screening and analysis of antibody binding and functional characterization.
In this webinar, Ethan Shelkey and Aurita Menezes will highlight key aspects in the design of cell-based assays.
Discover how alternative animal models provide new perspectives on physiological and biochemical processes.
Experts from the Women’s Brain Foundation and bit.bio will explore the importance of sex-specific in vitro models for neurological research and drug discovery.
Explore a comprehensive guide to standardizing large scale production and clarification of lentiviral vectors.
From foundational technologies to cutting-edge microfluidics, scientists use the latest wastewater surveillance techniques to track infectious diseases as they arise and spread.
Discover how mRNA modification, purity, and in vivo delivery affect expression and toxicity.
Multiomics platform streamlines workflows and provides real-time insights, optimizing resource usage and ensuring smooth, data-driven operations
