Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin biosynthesis with a potential role in promoting colon carcinogenesis, but the mechanism of COX-2 overexpression remains unknown. In December 1 Journal of Clinical Investigation, Dan Dixon and colleagues from University of Utah, Salt Lake City, USA, show that altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.The COX-2 mRNA carries an A/U-rich element (ARE), a cis-acting
Cyclooxygenase-2 (COX-2) is a rate-limiting enzyme in prostaglandin biosynthesis with a potential role in promoting colon carcinogenesis, but the mechanism of COX-2 overexpression remains unknown. In December 1
The COX-2 mRNA carries an A/U-rich element (ARE), a
These results provide a mechanism to link the control of COX-2 expression at a posttranscriptional level and tumorigenesis. In the light of these findings other specific regulators of ...
These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".
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Ten-year Agreement to Provide a Secure, AI-enabled Forensic Laboratory Information Management System Supporting DHS Forensic, Scientific, and Testing Services
deliver robust, reproducible solutions for sample preparation enabling a new era of end-to-end standardization in proteomics
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Enables ultra-low variant detection across a range of key MRD targets in AML, including very large FLT3-ITDs
