Accessing Drugs for Medical Aid-in-Dying

A fraught market for the barbiturates prescribed to terminally ill patients who choose to end their lives has physicians turning to options outside big pharma.

Written byCatherine Offord
| 9 min read

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©ISTOCK.COM/KATARZYNABIALASIEWICZIn early 2015, the price of the insomnia drug Seconal doubled overnight to around $30 per 100 mg capsule. The drug’s active ingredient, a barbiturate called secobarbital, was widely prescribed in the mid-20th century as a sleeping pill, before falling out of favor due to abuse, accidental overdoses, and the emergence of benzodiazepines as a safer alternative. Despite declining numbers of prescriptions, Seconal’s price has soared in recent years; costing just $2 per capsule in 2009, the drug retailed around $15 by the time its previous owner, Marathon Pharmaceuticals, sold the rights to Seconal in February 2015 to its current supplier, Canada-based Valeant Pharmaceuticals, which quickly raised the price to $30.

So why the rise? Just one month prior to Seconal’s price hike, California had proposed legislation that would make it the fifth state to allow medical-aid-in-dying, in which terminally ill patients given less than six months to live could choose to end their own lives with a physician’s prescription for a lethal quantity of a drug—Seconal being the drug of choice. Valeant denied ulterior motives for the decision. But some health-care practitioners called the move exploitative, whether or not the timing was deliberate. With Seconal’s climbing cost, the standard lethal-dose protocol—emptying 100 capsules into a beverage—has a price tag of $3,000 or more. “‘Shocked’ is one word you could use,” says David Grube, a family doctor in Oregon and national medical director of the nonprofit ...

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  • After undergraduate research with spiders at the University of Oxford and graduate research with ants at Princeton University, Catherine left arthropods and academia to become a science journalist. She has worked in various guises at The Scientist since 2016. As Senior Editor, she wrote articles for the online and print publications, and edited the magazine’s Notebook, Careers, and Bio Business sections. She reports on subjects ranging from cellular and molecular biology to research misconduct and science policy. Find more of her work at her website.

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