Physiologically relevant models were, in recent history, thought of as the holy grail in life science research. However, with three-dimensional (3-D) cell culture models now better able to mimic in vivo conditions, living organism replicas are within sight.

The ability of 3-D cultures to mimic the microenvironment of in vivo tissues sets the technique apart. Compared to 2-D cultures, cellular models containing three-dimensions better represent intricate cell-cell interactions, more closely resemble the exquisite nature of cellular communication, and have matrices that are analogous to in vivo structures.

Download this eBook from The Scientist and PerkinElmer to find out more about:
How the third dimension affects cell behavior
The similarities and differences between 2-D and 3-D culture
Common 3-D culture models
Imaging and analyzing 3-D culture models

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