Another Eczema Gene Identified

Human variations in a gene that causes matted fur in mutant mice are tied to the skin malady.

kerry grens
| 2 min read

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WIKIMEDIA, AFROBRAZILIANEczema is a common skin problem that involves chronic inflammation and itching. Genetic studies of the disorder have homed in on mice with mutations in the filaggrin gene, which lead to defects in the skin's outer surface. Researchers have now identified a second culprit, a gene called Matt that encodes the transmembrane protein mattrin and whose variants are linked with eczema—not just in mice, but in humans, too.

Comparing thousands of people with eczema to those without, the researchers found that a single nucleotide polymorphism in the human MATT gene was related to a small increased risk for the condition. It's not entirely clear yet what mattrin does, but it appears to also have a role in shoring up the skin against external stresses. “Sequence homology suggests a possible role for mattrin in the biology of lipids or lipid-like molecules,” the authors wrote in their study, published September 30 in The Journal of Allergy and Clinical Immunology.

It would make sense for eczema-related genes to have some role in skin defenses. “Without an intact skin barrier, foreign substances can enter the body and trigger inflammation and allergy,” study coauthor Irwin McLean, the scientific ...

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  • kerry grens

    Kerry Grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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