Arguments Heard in CRISPR Patent Battle

The highly publicized legal fight over the intellectual property rights for CRISPR gene-editing technology comes to a head, as both sides present oral arguments.

Written byJef Akst
| 5 min read

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US Patent and Trademark Office CRISPR patent hearingFLICKR, ALAN KOTOKThe line started to form outside the US Patent and Trademark Office (USPTO) before 8:30 this morning. By 9:30, there were far more people gathered than would be allowed in.

The crowd had gathered in Alexandria, Virginia to watch oral arguments in ongoing patent dispute of CRISPR-Cas9 gene-editing technology. CRISPR stands to change the way scientists edit DNA, and thus could be worth billions of dollars. Two key parties stake claims to that market: the Broad Institute of MIT and Harvard, and the University of California, Berkeley.

In May 2012, Jennifer Doudna of UC Berkeley and colleagues (including Emmanuelle Charpentier, formerly of the University of Vienna) filed a provisional patent application, describing her team’s ability to use the gene-editing pathway in vitro. “[Doudna’s team] does mention eukaryotic cells but is light on the details on how to scale that technology,” Jake Sherkow of New York Law School said at a briefing following the oral arguments.

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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