Credit: © Helen McArdle / Photo Researchers, Inc." /> Credit: © Helen McArdle / Photo Researchers, Inc. The paper: M.F. Fraga, et al. ?Epigenetic differences arise during the lifetime of monozygotic twins.? Proc Natl Acad Sci, 102:10413?4, 2005. (cited in 91 papers) The finding:

Credit: COURTESY OF ELSEVIER" /> Credit: COURTESY OF ELSEVIER The paper: E. Weisberg et al., "Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl," Cancer Cell, 7:129-41, February 2005. (Cited in 89 papers) The finding: Imatinib (Gleevec) stunned the world with its high cure rate for chronic myeloid leukemia through the inhibition of tyrosine kinase Bcr-Abl. But, BCR-ABL mutations are a common cause of relapse

Credit: © Aleksandr Lukin" /> Credit: © Aleksandr Lukin The paper: S.E. Schriner et al., "Extension of murine lifespan by overexpression of catalase targeted to mitochondria." Science, 308:1909-11, 2005. (Cited in 107 papers) The finding: Peter Rabinovitch at the University of Washington at Seattle and his colleagues found that transgenic mice overexpressing the antioxidant enzyme catalase in their mitochondria lived nearly 20% longer and exhibi

Findings suggest the effects of caloric restriction on aging stem from both less food and less of a sensation of food

Credit: PROFESSORS PIETRO M. MOTTA © TOMONORI NAGURO / PHOTO RESEARCHERS" /> Credit: PROFESSORS PIETRO M. MOTTA © TOMONORI NAGURO / PHOTO RESEARCHERS The paper: R.B. Seth et al., "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3." Cell, 122:669-82, 2005. (Cited in 77 papers.) The finding: The innate immune system recognizes viral infections inside cells with RIG-I and triggers type I in

Mutations leading to identical amino acid sequences can change protein folding and function

Credit: © Ed Hidden" /> Credit: © Ed Hidden The paper: U. Ozcan et al., "Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes," Science, 306:457-61, Oct. 15, 2004. (cited in 111 papers) The finding: The connection between obesity and type 2 diabetes is undeniable, but also unclear. In 2004, Gökhan Hotamisligil's group at Harvard School of Public Health showed that obesity physically strains the endoplasmic reticulum (ER) of

At least 12 percent of the genome is made of regions that vary in number across individuals, according to four new papers

Early findings suggest Neanderthal and human DNA diverged about 500,000 years ago

Some purported pairings are actually just random interactions between molecules, a new report claims

Transgenic mice with lower core body temperatures have markedly longer lifespans

By Charles Q. Choi Getting Results You've started a diversity program. But how do you know if it's having any effect? Harvard Medical School has offered a voluntary diversity-training program every year since 2000. Immediately after each session, organizers asked how much volunteers liked learning about the importance of diversity for organizations. People