Articles by Charles Q. Choi

The changes may help explain the link between maternal infection and autism, though more research is needed.

Maternal infection during pregnancy may be associated with autism, as previous studies have suggested—but perhaps not in a causal way.

Apoptosis and other types of programmed cell death appear to be reversible.

Molecular programs can rescue cells already engaged in the process of apoptosis or other forms of programmed cell death.

Shire Pharmaceuticals: A Study in Exponential Growth By Charles Q. Choi RELATED ARTICLES Successful Strategies Margaret Foti: Devoted to cancer research The Launch and the Exit Entrepreneurs Boldly Break New Ground Mark Tykocinski: Open doors lead a scientist to his calling Many Happy Returns: Cephalon celebrates its 20th year Creative Collaboration It's not every company that can go from $7 million in revenues to more than $1.7 billion

Many Happy Returns By Charles Q. Choi Cephalon marks its 20th year RELATED ARTICLES Successful Strategies Margaret Foti: Devoted to cancer research The Launch and the Exit Entrepreneurs Boldly Break New Ground Mark Tykocinski: Open doors lead a scientist to his calling Shire Pharmaceuticals: A Study in Exponential Growth Creative Collaboration Cephalon, the leading independent biotechnology firm in Pennsylvania and the Greater Philadelphia region

Populations that eat more starch carry more copies of carb-digesting saliva gene

Frequent lateral gene transfer from bacteria to their host organisms may be a mechanism for hosts' evolution

Light-activated proteins regulate virulence

Mutations in regulatory sequences may be the main drivers of species divergence

New genome transplantation technique works in bacteria, and could ultimately enable synthetic biology

Back-to-back studies pose double-strand breaks as initiating tumorigenesis.

Credit: © Helen McArdle / Photo Researchers, Inc." /> Credit: © Helen McArdle / Photo Researchers, Inc. The paper: M.F. Fraga, et al. ?Epigenetic differences arise during the lifetime of monozygotic twins.? Proc Natl Acad Sci, 102:10413?4, 2005. (cited in 91 papers) The finding:

Credit: COURTESY OF ELSEVIER" /> Credit: COURTESY OF ELSEVIER The paper: E. Weisberg et al., "Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl," Cancer Cell, 7:129-41, February 2005. (Cited in 89 papers) The finding: Imatinib (Gleevec) stunned the world with its high cure rate for chronic myeloid leukemia through the inhibition of tyrosine kinase Bcr-Abl. But, BCR-ABL mutations are a common cause of relapse

Credit: © Aleksandr Lukin" /> Credit: © Aleksandr Lukin The paper: S.E. Schriner et al., "Extension of murine lifespan by overexpression of catalase targeted to mitochondria." Science, 308:1909-11, 2005. (Cited in 107 papers) The finding: Peter Rabinovitch at the University of Washington at Seattle and his colleagues found that transgenic mice overexpressing the antioxidant enzyme catalase in their mitochondria lived nearly 20% longer and exhibi