Registry Review Casts Doubt on Causal Link Between Maternal Infection and Autism

Maternal infection during pregnancy may be associated with autism, as previous studies have suggested—but perhaps not in a causal way.

Written byCharles Q. Choi and Spectrum
| 4 min read
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Infection during pregnancy may be associated with having an autistic child simply because mothers of autistic children are prone to infections, a new study finds.

The results suggest that “common infections during pregnancy do not seem increase their children’s risk of autism,” says study investigator Martin Brynge, a psychiatrist and doctoral student of global public health at the Karolinska Institutet in Stockholm, Sweden. “Prevention of maternal infections would likely not affect the prevalence of autism in the population.”

A great deal of previous research has linked maternal infection during pregnancy with autism and intellectual disability in children. Whether the former causes the latter, however, has remained uncertain. For instance, both autism and intellectual disability are linked with gene variants that may influence the immune system, so mothers of children with either condition may also just be more vulnerable to serious infections.

The new study analyzed data from 549,967 children, including ...

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