Stem cells recruited to sites of infection may suppress immune cells in mice, and create a persistent infection

A GSK scientist spends his leisure time building makeshift photography equipment to capture some uniquely beautiful images

By Cristina Luiggi Equations that Spell Disaster Researchers are pinpointing the factors that combine to produce complex diseases. Juan Carlos Solon When Hurricane Katrina made landfall on the Gulf Coast in August 2005, the Category 5 storm caused such severe and lingering damage because it encountered the perfect combination of vulnerabilities: weak infrastructure, poor lines of communication, and a dysfunctional emergency rescue system. These conditions coale

By Cristina Luiggi The Philadelphia Chromosome, circa 1960 Related Articles New Smoking Gun? Cancer Genetics Gets Personal New Medicine Means Research RethinkLess than a decade after Watson and Crick published their landmark paper on the structure of DNA, two Philadelphia researchers noticed that the blood cells of patients with chronic myelogenous leukemia (CML) had an unusually tiny chromosome. At a time when the genetic underpinnings of disease were unc

A snapshot of the most highly ranked articles in biochemistry, from Faculty of 1000

A normal enzyme joins forces with its mutant form to result in certain human lymphomas

For physicians and researchers alike, fecal transplants present an opportunity to gain insight into disease

By Cristina Luiggi Gut reactions Courtesy of Ivaylo Ivanov, Dan Littman, and Doug Wei The paper H.J. Wu et al., “Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells,” Immunity, 32:815-27, 2010. Free F1000 Evaluation The finding The trillions of microbes that reside in the human gut shape their host’s immune system—for better or for worse. In a mouse model of autoimmune arthritis, Di

By Cristina Luiggi Meet and Greet How successful networking will make you a better scientist © Images.com/Corbis Howard G. Adams had a master plan for the American Association for the Advancement of Science’s (AAAS) 150th anniversary celebration in Philadelphia in 1998. He had been invited to join a panel discussion, and arrived way before the bulk of the attendees in order to lay the groundwork for achieving his one goal: to shake the hand of then

By Cristina Luiggi The Pee-in-a-Cup Test, circa 1500 Before X-rays and MRIs could peer inside the human body, physicians turned to bodily wastes, particularly urine, in order to make diagnoses. The practice of uroscopy arose from the observation that the color, consistency, smell, and even taste of urine change with different ailments. With a sample of the ailing person’s urine, physicians and laymen alike turned to widely popular illustrations known as urine whe

By Cristina Luiggi Genome blossoms Tom Misteli on the effort to produce the most detailed 3-D model of a eukaryote’s genome to date Understanding how DNA is folded, wound up, and packaged inside nuclei provides an additional layer of biological information to what’s written in the base pairs sequences. F1000 Faculty Member and National Cancer Institute cell biologist, Tom Misteli, discusses a paper that presents a high-resolution map of the yeast gen

Check out the highest F1000-ranked articles in biochemistry and related areas