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Analysis of PNAS articles suggests that open access papers are cited more heavily than subscription-based articles

Protein binding sites often are represented by "consensus sequences," such as TATA(A/T)A(A/T), "which report the most common nucleotide at any given position but eliminate much of the possible variability. In 1991, National Institutes of Health research biologist Tom Schneider developed an alternative, graphical approach, called sequence logos.In a sequence logo, the height of each position measures how well conserved it is, while the height of each character within that po

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How to keep your high-performance liquid chromatography running smoothly

insert urlClick to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN" />insert urlClick to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN The two chips illustrated below represent the next generation of high-performance liquid chromatography (HPLC). Their manufacturers - Agilent Technologies and Nanostream - have miniaturized and simplified the traditionally reagent-intensive process with microfluidics in order to boost sensitivity and thro

Credit: RENATO PARO" /> Credit: RENATO PAROEarly in the summer of 1991, Valerio Orlando, a postdoc in Renato Paro's lab at the University of Heidelberg, began working on the problem of identifying where proteins bind to chromatin in vivo. Researchers had already figured out how to determine whether a particular protein bound to a specific sequence in vitro. But what about protein occupancy in a living cell?Orlando and Paro's idea was simple: Crosslink protein-DNA complexes using

Link between new neuron growth and environmental enrichment-facilitated behavioral effects questioned in new mouse study

Unconventional class I myosin motors implicated in establishment of situs inversus

FEATURELSIA 2006 Our fourth annual event celebrates excellence in life science product development and services BY JEFFREY M. PERKEL AND ISHANI GANGULI It has been said that scientists stand on the shoulders of giants. Generally that refers to researchers' intellectual forebears, but it also is true of the life science industry - technology giants that provide the scientific community with the tools, equipment and

Credit: © TED SOQUI/CORBIS" /> Credit: © TED SOQUI/CORBIS With its tropical climate and persistent moisture, New Orleans has long been a hotbed of fungal disease and research. But when hurricane Katrina blew through, the town quite literally became one giant mycology laboratory. "We're the mold capital of America now," says Seth Pincus, director of the Research Institute for Children at Children's Hospital, New Orleans. Mold is everywhere, on everything. Pincus, an immunologist,

Credit: © 2004 NATURE PUBLISHING GROUP" /> Credit: © 2004 NATURE PUBLISHING GROUP With all the hubbub surrounding microRNAs in plants and invertebrates after their discovery, it was only a matter of time before a functional role was found in mammals. In 2004, graduate student Soraya Yekta, and Whitehead Institute for Biomedical Research member David Bartel found a role for microRNA miR-196 in HOXB8 regulation in mice.1 Naturally, it was assumed such a mechanism would exist in mammals. But