Jeffrey M. Perkel
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Articles by Jeffrey M. Perkel

An Archaeal pathogen?
Jeffrey M. Perkel | | 3 min read
AN ARCHAEAL PATHOGEN? X-ray from a necrotic tooth containing a periapical bone lesion Credit: COURTESY OF MORGANA ELI VIANNA" />AN ARCHAEAL PATHOGEN? X-ray from a necrotic tooth containing a periapical bone lesion Credit: COURTESY OF MORGANA ELI VIANNA The rogue's gallery of human pathogens is filled with members of the Bacteria and Eukaryota domains of life. Notably absent is the third domain: Archaea. According to a recent report in the Journal of Clinical Microbiology, however,

The Big Picture in Microbial Genomics
Jeffrey M. Perkel | | 5 min read
A revolution aids the study of unculturable microorganisms

Give P2P a Chance
Jeffrey M. Perkel | | 3 min read
Why you should be using peer-to-peer networks to share your data.

Which Transcription Factor Assay Should You Use?
Jeffrey M. Perkel | | 4 min read
Five ways to match DNA sequences with their cognate binding proteins

Atomic Force Microscopy
Jeffrey M. Perkel | | 1 min read
http://www.the-scientist.com/article/flash/23821/1/ Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN" />http://www.the-scientist.com/article/flash/23821/1/ Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN Invented in 1986 atomic force microscopy (AFM) has become a valuable tool for life scientists, offering the ability to image aqueous biological samples, like membranes, at nanometer resolution. The technique is akin to

Why You Should Be Annotating
Jeffrey M. Perkel | | 3 min read
Scientists who rely on accurate gene predictions should share in the burden of creating them

Upgrade Your Lab to TIRF
Jeffrey M. Perkel | | 4 min read
Why spend six figures on a new total internal reflection fluorescence system when you can upgrade your existing microscope for just $30,000?

TIRF Microscopy
Jeffrey M. Perkel | | 1 min read
/article/flash/23556/1/Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN/ACKNOWLEDGEMENT: MICHAEL DAVIDSON" />/article/flash/23556/1/Click to view enlarged diagram Credit: ILLUSTRATION: ANDREW MEEHAN/ACKNOWLEDGEMENT: MICHAEL DAVIDSONStick a soda straw into a glass of water, and from the side, the straw will appear to bend at the interface between air and water. That effect is caused by the different refractive indexes of the air and water, which causes the li

The Discovery of Reverse Transcriptase
Jeffrey M. Perkel | | 1 min read
In the spring of 1970 two young investigators shook the foundations of molecular biology's "central dogma," which holds that DNA is transcribed to RNA, which in turn is translated into protein.












