Sex may offer an evolutionary advantage by increasing the speed of adaptation.

A set of 17 genes distinguishes between metastatic and primary tumors.

Comparing human and mouse sequences identifies many conserved blocks on human chromosome 21.

60,000 full-length mRNA transcripts from the mouse genome cloned and characterized.

An international consortium has generated a high-quality draft sequence of the mouse genome.

CTCF regulates differential methylation and the action of an imprinting control region.

Studies of aging in a number of model organisms have provided insights into the mysteries of longevity. In the November 29 Science, Blanka Rogina and colleagues add another piece to the aging puzzle, by investigating the relationship between histone deacetylases, caloric restriction, and longevity in Drosophila (Science 2002, 298:1745, November 29, 2002).Flies that are heterozygous for a null or hypomorphic mutation in the gene encoding the Rpd3 deacetylase live longer than wild-type controls. T

Analysis of radishes reveals the mechanisms that generate and maintain genetic correlations.

TRF2 acts as a core promoter recognition factor and directs transcription.

Antibodies against myostatin improve the phenotype of a mouse muscular dystrophy model.

Simple dinucleotide repeats are commonly found throughout the human genome, but their functional significance has been unclear. In an Advanced Online Publication in Nature Structural Biology, Jingyi Hui and colleagues describe an unusual role for a CA-repeat in regulating mRNA splicing (Nature Structural Biology, doi:10.1038/nsb875, 25 November 2002).The human endothelial nitric oxide synthase (eNOS) gene contains a polymorphic CA repeat, (CA)14-44, in intron 13 that has been linked to a risk fo

Completed, high-quality, genomic sequences for two rice chromosomes.