Decreased expression of Notch1 is pivotal in late stage human papilloma virus-induced cervical cancer.

Structural details suggest that HLA alleles DRB1 and DRB5 may both influence susceptibility to multiple sclerosis.

Gold nanoparticle probes labeled with oligonucleotides and Raman-active dyes can detect oligonucleotide targets better than PCR.

HIV-1 chooses active genes and local hotspots for integration in the human genome.

The avian H5N1 influenza virus outbreak in Hong Kong in 1997 proved to be highly virulent when first transmitted to humans, but the reasons for this virulence have remained unclear. In August 26 Nature Medicine, Sang Heui Seo and colleagues at St Jude Children's Research Hospital, Memphis, USA, show that lethal H5N1 influenza viruses, unlike other human, avian and swine influenza viruses, are resistant to the antiviral effects of interferons and tumor necrosis factor α (Nat Med 2002, DOI:10

Telomerase undergoes regulated intranuclear shuttling during the cell cycle.

HIV envelope glycoprotein complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques.

A fungal saponin-detoxifying enzyme mediates a two-step suppression of plant defenses.

Early reports that adult mouse bone marrow cells (BMCs) were capable of transdifferentiating into cells with neural characteristics in the central nervous system raised hopes of developing effective treatments for neurodegenerative disorders. But, in August 23 Science, Raymond Castro and colleagues at Baylor College of Medicine, Houston, US, show that bone marrow cells from mice do not transdiferentiate into neural cells in vivo (Science 2002, 297:1299).Castro et al. used C57Bl/6 (B6) mice, whic

Continuous stereocilia remodelling explains the duration of post-concert tinnitus.

New evidence suggests that mitochondrial DNA can be paternally inherited.

The discovery of T cell functional plasticity could help treat autoimmune disorders and cancer.