Early reports that adult mouse bone marrow cells (BMCs) were capable of transdifferentiating into cells with neural characteristics in the central nervous system raised hopes of developing effective treatments for neurodegenerative disorders. But, in August 23 Science, Raymond Castro and colleagues at Baylor College of Medicine, Houston, US, show that bone marrow cells from mice do not transdiferentiate into neural cells in vivo (Science 2002, 297:1299).Castro et al. used C57Bl/6 (B6) mice, whic
Early reports that adult mouse bone marrow cells (BMCs) were capable of transdifferentiating into cells with neural characteristics in the central nervous system raised hopes of developing effective treatments for neurodegenerative disorders. But, in August 23
Castro
These data suggest that 'bone to brain' transdifferentiation may not be a general phenomenon but may instead depend on the experimental system in which the hypothesis is tested.
The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.
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