Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan

Brain synapses use "kiss-and-run" vesicle cycling to maintain neurotransmitter release

genotype associated with most resistance are susceptible to BSE

controls capsaicin receptor thermal and chemical sensitivity

Loss of the adaptor protein SLP-65 is a primary cause of childhood pre-B leukemia

Central inhibition of fatty acid oxidation may be sufficient to suppress food intake

Lung SP-A and SP-D proteins kill bacteria by mediating cell membrane interactions

Vascular endothelial cell apoptosis regulates tumor response to radiotherapy

Mitochondrial function declines with age, leading to insulin resistance and type 2 diabetes

The bacteria Staphylococcus aureus and Streptococcus pyogenes use fibronectin-binding proteins (FnBPs) anchored in their cell walls to adhere and invade host cells, but how the largely unstructured Fn-binding repeats of bacterial proteins recognize the host fibronectin has been unclear. In the May 8 Nature, Ulrich Schwarz-Linek and colleagues from University of Oxford, show that pathogenic bacteria attach to human fibronectin through a tandem β-zipper (Nature, 423:177-181, May 8, 2003).Schw

Dysferlin is involved in resealing the holes in, and repairing the muscle membrane.

Dendritic cells facilitate HIV transmission by locally concentrating virus and T cells.