Comparative genomic hybridization (CGH) is a useful method for detecting chromosomal imbalances in tumor cells. In the April
To reduce hybridization background noise they decided to modify the DNA itself, rather than the glass support. Cai
They constructed arrays consisting of almost 1,000 mouse-DNA BACs and examined loss of heterozygosity (LOH) and amplification events in mouse tumors. The BAC technique could detect chromosomal abnormalities at...