BPA and Its Replacements Have Same Effects on Mice

The plastic ingredients BPS and diphenyl sulfone cause chromosomal abnormalities, and the effects can last for generations.

Written byKerry Grens
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Alarm over the plastic ingredient bisphenol A has led to marketing campaigns boasting BPA-free products—and a reasonable assumption by consumers that such labeling indicates greater safety. But the ingredients that substitute for BPA may act in much the same way as the original.

A study published today (September 13) in Current Biology finds pregnant mice exposed to the BPA substitutes BPS and diphenyl sulfone have offspring with chromosomal defects, and the abnormalities can persist for generations.

“This is disturbing but not unexpected,” Linda Giudice, a reproductive endocrinologist at the University of California, San Francisco, who was not involved in the study, tells Discover. “The replacements are the same class of compounds and they have the same mechanisms of action.”

This is not the first report that BPS and other BPA substitutes might yield the same untoward effects on animals. Several studies in zebrafish, for instance, have ...

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  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

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