BPA and Its Replacements Have Same Effects on Mice

The plastic ingredients BPS and diphenyl sulfone cause chromosomal abnormalities, and the effects can last for generations.

kerry grens
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

ABOVE: © ISTOCK, ANYAIVANOVA

Alarm over the plastic ingredient bisphenol A has led to marketing campaigns boasting BPA-free products—and a reasonable assumption by consumers that such labeling indicates greater safety. But the ingredients that substitute for BPA may act in much the same way as the original.

A study published today (September 13) in Current Biology finds pregnant mice exposed to the BPA substitutes BPS and diphenyl sulfone have offspring with chromosomal defects, and the abnormalities can persist for generations.

“This is disturbing but not unexpected,” Linda Giudice, a reproductive endocrinologist at the University of California, San Francisco, who was not involved in the study, tells Discover. “The replacements are the same class of compounds and they have the same mechanisms of action.”

This is not the first report that BPS and other BPA substitutes might yield the same untoward effects on animals. Several studies in zebrafish, for instance, have ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • kerry grens

    Kerry Grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours

iStock

Agilent BioTek Cytation C10 Confocal Imaging Reader

agilent technologies logo