Skip to main content

BPA Disrupts Zebrafish Neurogenesis

Exposure to bisphenol A or its alternative, bisphenol S, reduces the generation of new neurons in the embryonic animal’s hypothalamus, according to a small study.

Written byTracy Vence
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00

WIKIMEDIA, HTEINK.MINAn alternative to bisphenol A (BPA)—a known endocrine disruptor that is used to make certain plastics and epoxy resins—may also cause harm, according to a study on embryonic zebrafish published in PNAS this week (January 12). Researchers from the University of Calgary in Canada exposed the fish to low doses of BPA and its alternative, bisphenol S (BPS), finding that both compounds were associated with decreases in hypothalamic neurogenesis—of 180 percent and 240 percent, respectively.

The researchers noted that their study “is the first, to our knowledge, to show that bisphenol S, a replacement used in BPA-free products, equally affects neurodevelopment,” suggesting that “BPA-free products are not necessarily safe.”

But Steven Hentges, executive director of the American Chemistry Council’s Polycarbonate/BPA Global Group, is not convinced. “The relevance of this limited study on zebra fish to human health, as asserted by the authors, is not at all clear,” Hentges said in a statement (via Reuters). “The study examines effects of relatively high concentrations of BPA on zebra fish embryos in water, and the authors claim the results are directly relevant to humans.”

Meanwhile, Calgary’s Deborah Kurrasch, who led the study, expressed concerns regarding regulatory oversight of compounds like BPS. “A lot ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related Topics

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays