A CRISPR-Cas platform uses microfluidic droplets, encasing CRISPR components and DNA barcodes, and injects individual droplets into zebrafish embryos. The embryos are raised and then researchers link phenotypes to genotypes by sequencing the barcodes.
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Encasing CRISPR tools in oil droplets offers a fast-track approach to conducting extensive genetic screens in animals.

zebrafish

zebrafish in an aquarium

Epigenetics May Remember Ancestors’ Mutations

Zebrafish with fluorescent nervous system in green.

Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development

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DNA Damage Makes Zebrafish Sleepy

istock

How to Grow a Mouse Embryo in a Dish

A Simple Genetic Change Adds Limb-Like Bones to Zebrafish Fins

model organism, zebrafish, sponge, cell &molecular biology, genetics & genomics, enhancer, transcription, non-coding DNA, gene regulation, evolution

Regulators of Gene Activity in Animals Are Deeply Conserved

Michelle Gray Tracks Huntington’s in Different Brain Cells

Scientists Predict Fish Behavior from Real-Time Brain Monitoring

Image of the Day: Zebrafish Olfactory Epithelium

Sleep Is Critical for the Zebrafish Brain to Repair DNA Damage

Image of the Day: Water Sensors

Effects of Antidepressants Span Three Generations in Fish

immune cells in zebrafish gut

Image of the Day: Gut Feeling

Image of the Day: See Through

Image of the Day: The Birth of a Nervous System

Image of the Day: Single Origin

Image of the Day: Bundle of Nerves

Magnetic Microrobots Deliver Cells Into Living Animals

Studies Show How Cells Differentiate at Life’s Beginning

Image of the Day: Immune Cell In Action

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How Are Earwax and Body Odor Linked?

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“Man on Fire” Syndrome, Ion Channels, and the Quest for Safer Pain Treatments

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Moon Cycles and Menstrual Cycles

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Microplastics Build Up in Human Organs, Especially the Brain

Multimedia

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Scaling Lentiviral Vector Manufacturing for Optimal Productivity

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Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

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3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

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Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

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Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
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From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

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Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

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Putting Pathogens to the Test with Wastewater Surveillance

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Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

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Tecan introduces Veya: bringing digital, scalable automation to labs worldwide