Triclosan, a common ingredient of mouthwashes, inhibits the growth of
Resistance is rapidly developing to the few remaining anti-malarial drugs and thus new therapies are urgently needed. In the February
Namita and Avadhesha Suriola found that an injection of Triclosan completely cleared P. berghei from a mouse model of malaria. They determined that Triclosan is effective because it inhibits the action of a parasitic enzyme called FabI. This enzyme is part of the P. falciparum type II fatty acid biosynthesis pathway and is similar to the FabI enzyme that exists in plants and algae. It is likely that the site of fatty acid synthesis in the malarial parasite is the plastid organelle, thought to be ...
