In an embryo, the stem cells develop into specific organs under the influence of complex extracellular signals. Sonic hedgehog (Shh) plays an important role in this process but its signalling pathway is not entirely understood. In August 31 Science Gurtej Dhoot and colleagues from the University of Pennsylvania Medical Center identify a member of a family of conserved sulfatases, QSulf1, which is responsive to Shh signaling and has role in embryonic cell fate determination.Dhoot et al. identifie
In an embryo, the stem cells develop into specific organs under the influence of complex extracellular signals. Sonic hedgehog (Shh) plays an important role in this process but its signalling pathway is not entirely understood. In August 31
Dhoot
Identifying and understanding the mechanisms ...
Add The Scientist as a preferred Google source to see more of our trusted coverage.
A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.
View this Issue
Discover how single-molecule Fiber-seq is revealing unexpected mechanisms of transcription factor regulation, chromatin accessibility, and essential gene activation at CpG-island promoters.
Explore how emerging biomarker research and ultrasensitive multiplex proteomics are revealing molecular signatures associated with neurodegeneration, inflammation, and disease progression in amyotrophic lateral sclerosis (ALS).
Explore how in vivo CAR-neutrophil engineering and advanced light-sheet imaging are opening new avenues for studying and targeting glioblastoma and other solid tumors.
Explore practical strategies for designing, optimizing, and validating qPCR assays to improve specificity, reproducibility, and confidence across routine and high-throughput gene expression studies.
Automation can help to increase efficiency and reproducibility, but often comes at a significant cost. The ASSIST PLUS pipetting robot streamlines workflows at an affordable price, offering accessible automation with minimal programming requirements.
Corning® Cell Strainers are sterile, easy-to-use devices for rapidly isolating primary cells to consistently obtain a uniform single-cell suspension from tissues. Applications include stem cells and primary cells.
Real time imaging shouldn't outlast your cell surface stain. CellBrite® Steady: cell surface staining kits with fluorescent membrane dye plus enhancer for imaging live cell surface for several hours to days.
Partnership brings Monod Bio’s LuxSit luciferase and NovoBodies to SignalChem Biotech’s custom assay services
