2022—Cellecta, Inc. today announced the launch of the DriverMap™ Adaptive Immune Receptor (AIR) TCR and BCR kits, a family of multiplex-PCR, NGS-based assays that enable profiling of up to all seven T-cell receptor (TCR) and B-cell receptor (BCR) chains from the same sample, in a single tube, without need of specialized equipment.
Starting from a variety of immune sample type inputs—whole blood, tissue biopsies, FFPE and more—the DriverMap AIR kits use functionally validated primer sets which target the highly variable third complementarity determining region (CDR3) of the heavy chain of the respective T- and B-cell receptors, along with reagents for multiplex PCR, to yield NGS-ready libraries.Subsequent sequencing and analysis identify antigen-activated clonotypes which can provide insight into the adaptive immune response and is useful for a wide range of therapeutic and diagnostic applications.
“While there are numerous immune receptor profiling options available on the market today, there are none that ...
