Deciphering the regulatory codes that dictate developmental and tissue-specific patterns of transcriptional control is a formidable challenge. In the January 22 Proceedings of the National Academy of Sciences, Benjamin Berman and colleagues describe a computational approach to explore the grammar of cis-regulatory modules (Proc Natl Acad Sci USA 2002, 99:757-762).They focused on the Drosophila genome and searched for high, local densities of binding sites for multiple transcription factors (Bico
Deciphering the regulatory codes that dictate developmental and tissue-specific patterns of transcriptional control is a formidable challenge. In the January 22
They focused on the
An accompanying paper by Markstein et al. describes a similar study using clusters of binding sites to identify novel targets genes for the Dorsal transcription factor (Proc Natl Acad Sci USA 2002, 99:763-768). Both reports highlight the value of combining in silico predictions of cis-regulatory ...
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