The Slimb protein regulates the degradation of phosphorylated clock proteins.
The circadian clock is maintained by well-defined, daily fluctuations in the Period and Timeless proteins that negatively regulate the transcription of their own genes. In the November 14
Investigation of components of the SCF-mediated ubiquitin proteosome pathway led to the identification of the Slimb protein as an essential cog in the fly brain clock. The
This is the first characterized example of a proteosome degradation protein that regulates ...
In mammals, intracellular clocks begin to tick within days of fertilization.
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