Counting Cells

A person likely carries the same number of human and microbial cells, according to a new estimate.

Written byJef Akst
| 2 min read

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Human blood prepared on a slideFLICKR, SMALLER.PATHOLOGICAL.CAMicrobiologist Thomas Luckey, who in 1972 estimated that the number of microbial cells in and on the human body outnumbers those carrying the human genome by 10 to 1, was wrong: people are not more microbe than human, scientists now suggest. According to new research from scientists in Israel and Canada, a 5”7’, 20-year-old man weighing 70 kilograms (154 pounds) likely harbors some 30 trillion human cells (the vast majority of which are red blood cells) and 39 trillion bacteria.

“The numbers are similar enough that each defecation event may flip the ratio to favour human cells over bacteria,” the researchers wrote in a paper posted to the preprint server bioRxiv last week (January 6).

“One-to-one is pretty impressive,” Judah Rosner, a molecular biologist at the National Institute of Diabetes and Digestive and Kidney Diseases who questioned the 10-to-1 ratio in a 2014 issue of Microbe, told Science News. “There’s as much of them as there is of us.”

Of course, the new estimate could be off by as much as 25 percent, the researchers noted, as it’s based on existing experimental data that could inform an assessment of human and microbial cell counts, such as estimates of bacteria in 1 gram of feces and ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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