COVID-19 Vaccine Trial Pauses After Adverse Reaction

The hold will likely delay trial results, and scientists say the pause is proof that safety protocols in clinical trials are working as they should.

amanda heidt
| 4 min read
COVID-19, SARS-CoV-2, coronavirus, pandemic, AstraZeneca, University of Oxford, clinical trial, adverse effects, safety, FDA

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Update (September 14): Oxford University and AstraZeneca announced Saturday, September 12, that they will be resuming their UK trials after a temporary pause following a case of transverse myelitis in a UK patient.

A series of late-stage clinical trials establishing the effectiveness and safety of a joint AstraZeneca and University of Oxford COVID-19 vaccine are on hold after one UK participant in a Phase 3 trial developed a severe and unexplained illness.

The incident was first reported on Tuesday (September 8) by STAT. The pause will delay results from one of the world’s largest COVID-19 vaccine development efforts. A company spokesperson says the measure has been taken out of an abundance of caution.

“This is a routine action which has to happen whenever there is a potentially unexplained illness in one of the trials, while it is investigated,” AstraZeneca shared in a prepared statement. “We are ...

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Meet the Author

  • amanda heidt

    Amanda Heidt

    Amanda was an associate editor at The Scientist, where she oversaw the Scientist to Watch, Foundations, and Short Lit columns. When not editing, she produced original reporting for the magazine and website. Amanda has a master's in marine science from Moss Landing Marine Laboratories and a master's in science communication from UC Santa Cruz.
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