Gene Activation by CRISPRa: Optimizing Overexpression for Gain-of-Function Studies

Horizon Discovery invites you to join them for an educational webinar.

Event Details:Gene Activation by CRISPRa: Optimizing Overexpression for Gain-of-Function Studies Date(s):

FREE Webinar

Wednesday, May 6, 2020
2:30 - 4:00 PM, Eastern Standard Time

Register/ Watch On-Demand Now

CRISPR-based methods have opened new possibilities for scientists studying gene function. While CRISPR knockout is the most discussed tool, CRISPR activation (CRISPRa) is becoming the preferred method for gene activation and overexpression for gain-of-function studies. In this webinar sponsored by Horizon Discovery, Steve Smith from Horizon will discuss how harnessing the specificity of CRISPR to activate or overexpress a gene within its endogenous context adds a powerful alternative approach to studying pathway components that may go undetected by loss-of-function analysis.

The consistency of the single-guide format associated with CRISPRa gene expression solves many of the challenges related to traditional vector-based approaches, including minimizing differences in expression and transfection due to transcript sizes.

Topics to be covered

Register/ Watch On-Demand Now

Meet the Speaker:

Steve Smith, PhD, MBA
Product Manager, Gene Modulation
Horizon Discovery

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Eppendorf Logo

Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

Evident Logo

EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

Evident Logo

EVIDENT Launches Sixth Annual Image of the Year Contest

10x Genomics Logo

10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research