Myelin sheaths are critical for efficient signal transmission along axons. Their inactivation could explain some of the neuropathological deficits associated with schizophrenia.
In the April 10
The team found that of 89 genes that were differentially activated in the schizophrenic group, only those involved in myelination were downregulated or activated at lower levels than normal. They emphasize that this suggests that oligodendrocytes could be a specific cell-type that is functionally impaired in schizophrenia.
Hakak's group stress that their findings support the observation that myelination of the prefrontal cortex occurs in late adolescence and early adulthood, the typical age of onset for schizophrenia. In addition,...